Ahhh. I remember some 486s that used to cause visible interference on nearby TV sets - and how the interference went away when I OCed a 40MHz processor to 50 MHz.
AFAIK, the material that motherboards are made of can easily support data rates in the GHz range, like PC1066 RDRAM, Serial ATA, AMD Hypertransport, even the Rambus Yellowstone bus at 3.2 GHz. It's mostly a matter of controlling crosstalk, skew, SSO noise, reflections, and at >2 GHz skin effect, that sort of stuff. Radiation can be kept down by sandwiching signal traces between ground layers if needed.