I really don't think it's going to be another Final Fantasy. Final Fantasy XII is not even out yet, and I don't think that Square Enix wants to upstage that. (They haven't even announced the FF in development for the PS3) It could be a DQ, but I don't see SQEX releasing their biggest title on a console that almost certainly won't be the biggest in Japan. (Possibly a remake?) Oh, World of Mana. If you remember, Square Enix only announced that it was for next-gen, so maybe that could be the surprise. Possibly Konami's flagship title for the system, as well as Ridge Racer for it, those are my guesses.