Played Prototype for a few hours last night and am pleasantly surprised. Actually I expected this to be another poor port like GTAIV or Saints Row 2 with astronomical minimum specs, but it doesn't seem to be the case. No crashes yet, No bugs discovered (yet!) and I am very surprised how much I am enjoying it.
The presentation is rock solid, with 360 console gfx reminiscent of Mercenaries or Lost Cause. The nice gritty art direction helps lift it above that dross though. The gfx and textures are crisp/clean and whilst hardly breaking any new ground they do the job well enough. I play at 1680x1050, 16xAF, 4xSSAA, Triple Buffering and VSYNC on (Forceware set to HQ mode) and hit 50 - 60 fps easily. My rig is C2D @ 3.4GHz, 4GB, GTX260 (216) and Vista x64. I might post some screenshots later.
Controls are a tad clunky either with a 360 joypad or the usual k/m mouse combo but not bad enough to ruin it, although in the larger fights, and there are quite a few, the camera movement and targeting system can get frustrating.
The good bit is the gameplay is absolutely fantastic! It really is easy to pick up and play and you really do feel extremely powerful even from the 1st non-tutorial level. The story is very engaging and the cutscenes, both CG and real time are very well accomplished. Imagine playing Spiderman, with the power of The Hulk and the recovery powers of Wolverine!...
... Well thats what it is like, Awesome!