Well, maybe I could, but I'm not sure if I even want to take part in this. None of the ideas so far have got me hooked.
Something I always wanted to do:
"Any sufficiently advanced technology is indistinguishable from magic." - Athur C. Clarke
To most people, high-tech, electronics, computers and most everything else scientific is exactly like magic. It either works as advertized, or they'll call in the wizard to fix it.
So, let's take a look at magic. Basically, there are three kinds of it: chemistry and/or biology with spectacular effects, incantations learned and executed, and granted by a Deity. Translated to science, the first one is easy: exposives, medicines and their likes. The second is as well, if you replace "incantation" by "program". And the third is as well: your Deity is the central computer.
Imagine a very high-tech environment, run by a single Deity, like a PC and CPU. And see the players like programs, services or even virusses.
Now, forget anything about computers or computer terms, and replace all that with RPG magic. As an example, let's take lightning. You might evoke that with a metal rod, or by requesting a power surge through a terminal, or by asking the CPU. The result is the same.
Now we'll take the player through a journey that starts them off as midieval RPG characters, dumped into an "alternative plane of existance", that happens to be the inside of a computer. They just do the RPG thing, as they are used to, and it works. But it takes them the whole game to find out why and how it works. Which they need to "level up", so to say.
As we're talking not only about the history of computers, but of role-playing and games as well, you can take this any way you want. I always fancied a game that is extremely easy to win, in minutes or even seconds, but you can forefeit that as long as you want and just go along with it, eventually being turned into something resembling a God. The road being the accomplishment, winning not being the goal.
And finally, I believe a true artist can take something as boring as an eight bit sprite, and turn it into a truly horrifying 3D monster. Like a flattisch zombie or such, which you cannot lose. It's slow, but nearly unkillable. Or they all have multiple lives. Or they're a vertical stack of animation frames: you only kill one of those each time. Etc.
But anyway, we all have to like the idea. So it might be a good idea to just let everyone tell us what they would ultimately want in a game, and see if we can distill that into something desirable.
Edit: you might want to replace CPU by OS or task manager or such in the above.