I'm trying to find a link to an alleged leak of some of Globalfoundries' test modules and some other presentations on it.
I think the last time I looked at some of the numbers, the largest rumored GPU size might have had problems with fitting the area of more than two stacks.
The highest-end rumored GPU could suffer from the even worse capacity and bandwidth constraints.
Economics in terms of cost per mm being higher and yield seems to be a major limiter of interposer size.
I've seen it pointed out that if the interposer's own process is coarse enough (Amkor talked about a 65nm process with a few metal layers), it is possible to "stitch" together multiple zones. Each zone would be an area compatible with the reticle.
Very large sensors do something like this, although I'm not familiar with that enough to know if the lower bound of that methodology is compatible with the needs of the memory interconnect. Alignment becomes too hard if the geometry gets too fine.
There are also interposer materials besides silicon, like glass, which have different limits and trade-offs. Since AMD and its closest partners haven't talked about that, I haven't really considered other materials.
edit:
Here's something I think is similar to what I looked at back then:
http://www.3dincites.com/2014/11/globalfoundries-3d-ducks-row/
The prototype interposer is ~830 mm2, and people where guessing at taking Hawaii and increasing it by 50% or more. The area starts to cut really close if things are taken that far.