Crysis looks great but really, what kind of rig will you need to make it look its best?
And then, its a shooter. Lord knows we need another one of those.
I think Little Big Planet looks great. Probably beaten by Crysis but not beaten in the innovation and gameplay department.
By the time Crysis releases there should be plenty of setups capable of maxing it out. Im thinking at least 4 single GPU's from Nvidia and another 2-3 from ATI.