Coronavirus Pandemic (COVID-19) (SARS-CoV-2) [2020]

Discussion in 'General Discussion' started by RDGoodla, Feb 4, 2020.

  1. wco81

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    Death numbers and articles about people losing loved ones get the most coverage.

    However, more and more, US media is reporting on the long-haulers, people who are not able to work or do physical activities to the same extent as before. This is months after getting infected.
     
  2. Arnold Beckenbauer

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  3. wco81

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    I don't think that this IP waiver will have immediate effect.

    Canada doesn't have factories so it's not like they could start making the mRNA vaccines on their own right now.

    Even if they had the factories, the processes for making the vaccines are not that easy to set up. So without their cooperation they won't get that far.

    India has the biggest vaccine manufacturing infrastructure but again, they're not going to be cranking out mRNA vaccines the day after the IP waiver without Pfizer and Moderna's cooperation.
     
  4. Mariner

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    The mRNA stuff is so new that pretty much nobody but Pfizer and Moderna can produce these vaccines at present, (though GSK/CureVac and Sanofi probably aren't too far away from the capability). IP waivers would potentially allow the adenovirus vaccines to be produced elsewhere, but you would be talking many months before these could be ramped up effectively. We've seen from the licensing deals with the AZ/Oxford vaccine that it's not necessarily an easy thing to get new manufacturing plants up and running quickly, even with support from the original manufacturers.

    If an IP waiver was brought about, I think it would be AZ/J&J doing most of the legwork. Novavax is a very interesting vaccine, but they are reliant on the special saponin adjuvant which is also used in the new Oxford malaria vaccine. Not something which can be mass produced as there aren't enough Chilean soapbark trees around (fascinating article about this: https://www.theatlantic.com/science...cies-may-hold-key-coronavirus-vaccine/616792/)
     
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  5. wco81

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    Yeah Novavax is having difficulties ramping up supplies for the contracts it signed with the US and Europe, let alone the rest of the world.

    Might be a good choice for a booster.
     
  6. AlphaWolf

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    mRNA isn't really that new, just the first approved for mass distribution.

    A canadian company actually developed and produces nanoparticles used in the pfizer vaccine.

    Novavax has an agreement to produce in Canada and will probably begin doing so early next year.

    It doesn't look like covid-19 is ever going away. New strains, slow world roll out and vaccination hesitancy mean achieving herd immunity is increasingly unlikely.

    We will be needing these vaccines in an ongoing fashion, in a faster rate than they have been delivered to date.

    There are still many vaccines in the pipe and it's likely they will be needed.
     
  7. pharma

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    Seychelles brings back curbs despite vaccination success - BBC News
    May 5, 2021
     
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  8. wco81

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    They vaccinated with Sinopharm.

    would be interesting to see how many breakthrough infections.
     
  9. wco81

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    Researchers are mapping the parts of the spike protein which are targeted by different levels of antibodies.

    For instance, they found that 84% of antibodies targeted parts of the spike protein outside the RBD.

    One such part is the NTD:

    https://www.sciencedaily.com/releases/2021/05/210505130541.htm

    OTOH, researchers have identified other parts which are less likely to have mutations yet still are targeted by relatively high levels of antibodies:

    I would imagine the designers of the first vaccines didn't have this level of detail about the different parts of the spike protein when they locked in their designs over a year ago.

    But they may not yet incorporate this information for boosters. Rather, we may have to wait for universal vaccines against different covid mutations or against different coronaviruses.
     
  10. Putas

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    Just like Chile. Only western vaccines seem reliable.
     
  11. Mariner

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    The Sinovac vaccine in Chile has actually been pretty effective. A study released last month showed 67% reduction in symptomatic infection, 85% reduction in hospitalisation, 89% reduction in admissions to ICU, 80% reduction in deaths. The issue is that this is based on data from 2 weeks after full vaccination. Lots of first doses given in Chile but a relatively low number of second doses. The Sinovac vaccine doesn't appear to be as effective after 1 dose as the Western vaccines in use.
     
  12. pharma

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    I read it as, by April 60% Sinopharm and 40% AstraZeneca (Indian made) made up vaccinated population.
    It would be helpful if they gave some numbers regarding re-infection and initial vaccine used.
     
  13. green.pixel

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  14. Davros

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    Is it surprising people who believe in magic do stupid things
     
  15. pharma

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    Mucormycosis: The 'black fungus' maiming Covid patients in India - BBC News
    May 9, 2021
     
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  16. green.pixel

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  17. Arnold Beckenbauer

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  18. Sxotty

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    Something something transparency...

    This has really highlighted some bad things about the current culture in different countries. Now the US has plenty of effective vaccine and people won't utilize it ...
     
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  19. Mariner

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    If the cases arose less than a week after the second dose, it would have been too soon for the 'boost' of the second dose to have had an impact. And, of course, the vaccines aren't 100% effective against any of the variants. The fact that all 15 survived with non-severe illness is encouraging as the mortality rate in care homes is likely to be pretty high. Hopefully, the vaccines do provide some decent protection against the "Indian" variants.
     
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  20. wco81

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    Perhaps a counter example, a small Brazilian city in the Amazon vaccinates most of its adults with CoronaVac, which is a Chinese vaccine showing only 50% efficacy in trials.

    https://www.sciencenews.org/article/coronavirus-pandemic-serrana-brazil-covid-mass-vaccine
     
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