The HPC APU scheduled for 2017 may have a TDP of up to 200-300 W.
Is it too much to hope for a consumer variant of that APU?
Would they actually need to do anything here? I would hope the minimum needed is a mobo with the appropriate form factor, and perhaps some modification to existing after market cooler designs. They could charge a pretty penny and still come out cheaper than the price of a high-end discrete GPU + DDR4 + high-end Intel desktop CPU. And they'd presumably offer ECC, which isn't available from Intel in any consumer product as far as I know.
Going further - this would also likely be very attractive for the high performance in a small form factor crowd. Personally, I would love a system with support for one or two NVMe SSDs (M.2 or 2.5"), a high performance/wattage APU with 16 or 32GB HBM, the usual outputs, an external power brick, ~250-300W, stuffed in a box not much larger than the double-height PCIe cards we see today.
Anyway whatever . I think they'd be idiots not to have some (relatively but not outrageously expensive) way for the high-end consumer market to get into one of these. Make it happen AMD!