If it's only niche, and we're talking sort of custom SFF PC's, I'd worry about the cost issue. I mean, if you can build a faster traditional PC for the same money, then we're dwindling the advantage down to almost just form factor alone, while also losing all ability to upgrade CPU, memory or GPU in the future which definitely has value.
Maybe Valve could try and bring back the 'Steam Machine', except do what they did with Steam Deck and subsidize the cost as much as practically possible in order to push adoption? That could maybe help get around lower volume cost issues.