A few things that I noticed from skimming through the video.Apparently it runs very well on an RTX 2080 laptop GPU (about 2070 Super performance) with a Samsung 970 Evo SSD, performance was in the range of 1440p, 40+fps.
* Guy mentioned they can run the demo in the editor at 40fps, not 40+ but did not specify resolution.
* Currently Nanite has some limitations such as only works on static meshes, doesn't support deformation for animation, doesn't support skinned character model, supports opaque material but no mask.
* Lumen costs quite a bit more than Nanite
* UE5 could eventually be a hybrid renderer using both Lumen and Raytracing in the future.
Did not watch the whole 135min lol.