It is very cute but here is my opportunity to state that the emperor has no clothes where it comes to F@H.
My instinct from reading is the science output of the project is minuscule. It is like Seti in this regard.
I think this is an entirely unfair characterization based on a strawman characterization. First of all, SETI's "science output" is a search for a counter example to the statement "there is no intelligent life anywhere else but earth within our lightcone", and as such, there is no incremental progress. It is all or nothing, and there is a very real possibility that a counter example can never be found because none exists. It's like funding "GoldbachConjecture@Home" searching for a counter example. About the only thing SETI@Home accomplished was to demonstrate that DC was feasible.
Folding is much different, and I think your characterization is asinine. You hold F@H to an impossibly high standard, that "output" consists of drugs or curing diseases. Much work in molecular biology today is basic, not applied research. Genomics, Proteomics, Transcriptomics, et al, are not worthless simply because they didn't immediately effect people's health. It's like some moron running around saying "The Human Genome Project has no clothes! It's been many years and no cure for cancer yet!" F@H has produced peer-reviewed results that have yet to be refuted.
What the average folding user thinks is irrelevent. The question is, is the CS research being done to design distributed algorithms for protein simulation of any intellectual value, and have large scale trials of the software turned up any new knowledge in computer science or biology, and I think the answer is unequivocably yes.
The job of fully and accurately simulating the incredible interactions of proteins within cells is orders of magnitude more complex than the simulation and the wider issues around doing so, and using the results, are orders of magnitude more complex as well. This is really just a big phd project that has, thru the "excitement" of distributed computing (which is mostly, to be frank, stat-whoring), been gifted with a very large but inefficient and EXTREMELY power hungry compute array.
Another red herring. So what's you suggestion? No simulations of protein folding should be bothered with, because we can't simulate the protein inside the cytoplasm, nor can be fully run entire virtual cell simulations? The hallmark of western science is reductionism, and we can and do glean useful information by simulating or analyzing small components of massively complex systems, rather than always dealing with everything holistically.
Sure, one can't neccessarily just take the output of F@H and completely predict what a protein will do inside of a single cell, not to mention a cluster of cells. But one can't climb stairs without taking the first step, and the first step to simulating more complex protein environments is to simulate the simplest possible. As far as distributed computing goes, even if you were to assume that BlueGene petaflop scale computing became affordable by major pharamceutical companies and universities, you'd still benefit from simulation code designed for distributed processing because as you point outself, at some point, you'd probably like to network together the petaflop machines to do even more complex work.
If you're interested in helping, calculate the power bill you'd save by not running F@H and then donate that money to a charity that buys vaccinations for the third world, or something like that. Most PCs go into heat/power overdrive running F@H in the "background". Leaving PS2 on vs off is over 200 watts as well. You can really make the argument that the scientific worth of folding at home is far counter-weighed by the power expense of running it.
Oh please. First of all, you could not even begin to calculate the economic benefit/scientific work of projects like this, because one can't predict scientific breakthroughs. So your purported cost-benefit argument is bunk. Scientific worth is unpredictable and serendipitious. Often pure research produces results which seemingly have zero real world applicable use, and then 20 years later, they turn out to have very important applications. R&D is essentially a search in a vast knowledge space, and that's why we must *wastefully* fund many many projects before a winner is found. It's why venture capitalists must invest in 40-100 companies on average before they turn out the unexpected breakthrough.
Secondly, the priority argument is a fallacy, as usually, it assumes all-or-nothing investment. But if you takes the tact that the $10-14/month spent running 200W 24-hr-a-day simulations would be better spent for vaccinations, you can also argue that one should not buy $3000 of HDTV equipment, or $400-600 of game consoles (4+ years of $10/mo support to the poverty stricken), or that people should drink 3 less StarBucks lattes per month, or that we money spent on Vista should go to the poor, and so on. It's a fallacy, especially for people who buy $400-600 consoles and HD setups, is that $10/month usually does not prevent them from doing other good. Or, rather than by an HDTV + console, they would have done far more good energy wise to buy a hybrid, higher MPG car, or install a solar or wind generating equipment (or purchased offsets)
And if you really want to argue the vaccine angle, the $10/mo spent on F@H work would be offset by cancelling your Xbox360 Live subscription, selling it on eBay, and buying a PS3 which has free online.
I think these DC projects are rarely brought into sunlight and forced to justify the value of their output vs their nett power consumption (to say nothing of the hours of installing/upgrading/mucking around that goes on).
If people were forced to justify power consumption like that, they may as well ban game consoles, TiVos, air-conditioning, and force everyone to live with LED light, because people's power usage is already so so incredibly wasteful. I mean, let's get real. So many people waste hundreds of watts leaving lights on, TVs playing, wasting water, wasting gas. Someone who runs an HVAC for 1 hour will consume the power of 17.5 PS3s running F@H.
Why should anyone have to justify their computing power project to you? How much power is wasted worldwide on stupid TV shows, how much power at internet data centers is wasted on nonsense like MySpace?
The power wasted by F@H is dwarfed by the overall wastage in our economy on mindless entertainment that does not produce any scientific output and is purely consumptive. You're complaining about drops leaking out of a bucket, when water is gushing out a huge gaping hole that is Idiocracy as we know it. I think the power wasted by American Idol alone puts F@H to shame.
Really, if you want to do the most environmental or health good, you'd do well to stop wasting electricity complaining about DC projects, and instead be a blowhard electricity waster campaigning for power conservation in other areas. If you spend an hour a day convincing people to cut down on A/C, drive less, or use less hot water, than whining about PS3s running F@H, you'd be more environmentally effective.
You could also convince people to stop buying mega powerful PCs and GPUs and gaming, and instead buy power efficient internet devices that consume 1/10th the power, and do 90% of what most people need to do.