I am ashamed to say 'Desperate Housewives' is actually pretty good.
As has been mentioned Black Books is pretty funny (Bill Bailey is a comedy genius), and if you like that then you should also try Spaced (by Simon Pegg, the guy who did Shaun of the Dead).
I personally like the fact that our seasons are short. It means that they are not trying to stretch the show out to fill a run of 24 shows.
These days i much prefer American Dad to Family Guy. Made by the same people, it's just so funny!! I probably prefer it because i've been through 5 seasons of Family Guy while American Dad is on his second one, but my god it's funny...