My main problem with all games like this (inc Torchlight/Diablo3 etc) is the gear you can buy from vendors. While I don't always want the high end stuff to be better than the highest end stuff I can craft, the items you can get while leveling from vendors invariably sucks.
I would *really* like currency in these worlds to matter. I have about 1mil septims in Skyrim, and nothing really to spend it on. I've never bought a weapon from a vendor because even the crap I've picked up on random quests is better. I would prefer vendors to have at least a couple of OTT items, that are 20-50k-500k to give me something to aim for, rather than lots of crap at 2k.
It just breaks my suspension of disbelief. The vendor in town in Diablo3 is all like "Ah traveller, look at these amazing weapons I've newly uncovered in the deepest mines, just for you!". My character is pretty much: "but that's no better than this axe I found on a pig in a cellar I walked into by accident". And the vendor then says "Indeed it is! It is MUCH better than this weapon I was going to charge you 2000gold for... how about I give you 50gold for it". "Piss off".
Bethesda/Blizzard, give your vendors ridiculous weapons @ ridiculous prices, for those of us that actually want to go out there and kill every mob to get every last gold piece!