According to
user feedback, the problem occurs only with AMD CPU and GPU combinations since that hardware supports the Ryzen Master SDK. So if you are running a system that has either an Intel CPU paired to a Radeon GPU, or a Ryzen CPU paired to an Nvidia GPU, you will not encounter this problem.
For some reason, AMD's Adrenalin software will automatically enable PBO or the "CPU OC" setting when applying GPU profiles -- including the Default profile, which happens automatically.