Got Rocksmith PC version as in-advance Christmas gift.
Bad stuff:
Latency sucks. After tweaking buffer sizes, it sounds like ~50ms latency - tolerable for game play, but not good enough for actual guitar playing.
The user interface is indeed one of the worst I've seen in a long time. No intuition in what keys to press at what point.
The first half an hour was really annoying, having to watch the narrative tutorials and beginner stuff. And the initial single note arrangements are quite antimusical, plus they expect you to play on one string, shifting fretting position continuously up and down, which is not exactly a good way to make someone learn to play guitar IMO. I really hope the more advanced parts make more sense in terms of actual guitar playing.
Good stuff:
The amp and effects modeling isn't bad at all. If only the latency could be cured...
The basic premise is good, and implementation of the pitch recognition seems surprisingly robust.
Did you try an analog output on your PC? My PC HDMI lag was awwful, but analog out is near perfect.