The new preview at 1up calls it "Diablo meets Devil May Cry", and goes into some detail about the control scheme. Melee is controlled with the right analog stick, and your left and right guns are controlled with the triggers. It's possible to hit your enemy up into the air by double tapping the right stick and then juggle them in the air with your guns, Devil May Cry style. Also, your guns lock on automatically (although this can be turned off), and you can actually shoot at different enemies simultaneously with your left and right guns.
This game needs to get here soon.