The DDR3 2000 CAS9 will take 9/2000 seconds, which is equal to 0,0045 seconds, to respond while the DDR3 1600 CAS 6 will take 6/1600, which is equal to 0,0038 seconds, to respond. Thus, the 1600 one is faster.
Less RAM sticks generally means less load to the memory controller. So, 2x4GB is better than 4x2GB.