yes.. that would require to build some big infrastructure on the moon. The biggest things we've done till now (Apollo, Mir, ISS) are nothing more than camping, how exactly would we move from camping to building a real moon base with mining, industry, big energy, life support from regolith, by 2020-ish no less.
what I can see is assembling a space ship in low earth orbit : tin cans that include nuclear reactors, ion drives, and the landing module.
Or, another idea : do nothing till the day we are able to produce antimatter in microgram quantities (or more, dunno), then start designing an interplanetary mission. that might be worth it cost-wise, even if one microgram costs $50 millions, you'd eliminate the hassle of sending either an awful lot of chemical fuel or nuclear reactors with their shielding.