That's it! Run the game and enjoy.
There is another step you need to use with
dxvk-async btw: Create a
dxvk.conf file in the same folder as the .dll's, and add:
dxvk.enableAsync = true
To enable asynchronus shader caching. Just the dll's alone will not do it.
God of War, the video's author mentions how it helps all AMD cards.
This was true for many DX11 games previously, however that video is 7 months old - this was well before AMD's new DX11 driver. That has significantly improved the CPU bottleneck in DX on midrange/lower-end CPU's now for Radeons, so dxvk is not really as necessary for these problem games on AMD GPU's anymore. Fixing AMD's CPU-bottlenecked DirectX drivers was a big reason DXVK on Windows started getting noticed.
On dxvk use as a whole across various GPU's:
Certainly dxvk can provide notable uplifts on some games in some scenarios, even on systems with stable DX9/11 drivers. For example on my I5-12400 and 3060, some areas in ME1 Legendary can have fps dip below 60fps at any res, likely due to single-threaded bottlenecks caused by the crappy DX9->DX11 migration EA did for the remaster. Dxvk can uplift those same problem areas to 120+ fps. Those are the likely areas where you may see the most benefits; games with extremely poor GPU utilization due to threading bottlenecks.
However, there are some caveats you should know as well that I've run into from my year+ of experimenting with it:
Compatibility. Bear in mind DXVK was created for Linux gaming first and foremost as part of Proton. As such, the bulk of its compatibility is focused on that platform. DXVK on Windows is basically off-label usage. If it works, hey great - but it's really not 'supported'. As such, there are a number of games where it will work perfectly in Linux, but fail to load on Windows. Arkham City and Origins are two such games that just crash when trying to run dxvk with the DX11 path (works on DX9). So there's really no place to go to report bugs on Windows, just gotta hope the next release happens to fix it.
Multiplayer. Shouldn't be too much of a surprise as you're replacing .dll's, but dxvk will not work with anti-cheat software. There is varying levels of success with this depending on the game and how aggressive its anti-cheat implementation is, but even it you get into a match without incident, there is the possibility it may be detected as a hack.
Latency. This can vary significantly per game, but ime dxvk has worse latency than DX when using Vsync. Just in general, but also because being Vulkan, you cannot take advantage of other latency-reducing options for DX9/11 titles, such as Low Latency or Fast Sync. Far less of a concern on VRR displays where you can just disable vsync of course.
Edit:
HDR: Almost forgot this. No HDR, and not available through SpecialK or AutoHDR on Windows 11 either. Prob not a huge loss for many on most PC displays but worth mentioning.