The consumer POV: Perhaps they won't take off, but if Epic, Ubisoft et all are supporting the product in their upcoming titles, then surely it can't just be a fly-by-night thing. After all, aren't the majority lot of end-users finally accepting both multi-GPU (SLI and Crossfire) and multi-core CPU (X2, Pentium D) as feasable- if very expensive when high-end- solutions to irreputably make thier PC games run better one way or another? Whether these solutions will last for another 5+ years is another story...
On the other hand, and not to be arguementative, but do you not see the PPU taking off in a big way? Why not, do you only see accelerated physics as being additional non-interactive eye-candy only? I know from reading the script of Carmack's 2005 QC speech he feels this way, he does not see the dedicated PPU as 'the next big thing' or anything like it...