I've seen a few glitching enemies. Other than that still haven't had anything really irritating happen. But I am only at like 8 hours on the game.
I am ~30 hours into the game...but still in Act 2.
I get sidetracked with Gigs, NPCD missions, passing crimes...and just exploring Nigth City...which is one of the first game-cities for ne that feel like a "real" city and not just a pretty back drop.
Oh...and do not return "Skippy"...lesson learned for next gameplay :/